Near Infrared Imaging Group

Grant # R01CA109558 Title: Fluorescence Imaging to Optimize Cancer Therapy
This study is devoted to studying how to use fluorescence from a mitochondrial activated compound to study cellular damage from radiation therapy, chemotherapy and photodynamic therapy, and to use this measurement technique to optimize combined therapies.

Grant # PO1CA80139 Progam Project Title: Alternative Methods for Breast Cancer Imaging
Project IV: Near infrared spectroscopy and imaging of breast cancer
Program project through the Thayer School of Engineering, Dartmouth College, Dartmouth-Hitchcock Medical Center to examine imaging methods based upon model-based image reconstruction, including microwave tomography, electrical impedance tomography, magnetic resonance elastography and near-infrared tomography. The latter method is examined in component IV, and uses near-infrared measurements to reconstruct images related to hemoglobin concentration and oxygen saturation within breast tissue.

Grant # R01CA120368 Title: Micro CT/NIR Molecular Imaging of Cancer
This study is devoted to developing a hybrid imaging system, combining fluorescecne tomography into a MicroCT system, and examining the optimal ways to detect multispectral data to recover images of tumors with molecular specificity.

Grant # PO1CA084203 Program Project Title: Physical and Biological Determinants for Optimal PDT
Project 3 Title: Online-measurement and Model-based dosimetry for PDT
This project develops fundamentally new technologies for use in PDT dosimetry, by combining basic laboratory measurements together with modeling studies.

Grant # R33CA100984 Title: Spectral-Encoding for Video-Rate Hemodynamic Tomography
This study is devoted to construction and testing of a new hardware design for video rate near-infrared hemoglobin imaging, to be tested in small animals. The system involves spectral encoding of the light source location to allow parallel source implementation.

Grant # U54CA105480 Network Project Title: Breast Cancer Multi-dimensional Diffuse Optical Imaging
Project 2 Title: Spatial/Spectral Tomography for Localized Functional Spectroscopy
This project is focused on developing a spectrally enhanced optical tomography system for retrieving pathophysiologic measurements from breast tissue. The research is carried out in collaboration with colleagues at University of Pennsylvania, University of California Irvine, and the Massachusetts General Hospital.